Mirabilis multiflora is a species of flowering plant in the four o'clock family known by the common name Colorado four o'clock that is native to the southwestern United States from California to Colorado and Texas, as well as far northern Mexico, where it grows in mostly dry habitat types in a number of regions.

It is a perennial herb growing upright to about 80 centimeters (31 in) in maximum height. The leaves are oppositely arranged on the spreading stem branches. Each fleshy leaf has an oval or rounded blade up to 12 centimeters (4.7 in) long and is hairless or sparsely hairy. The flowers occur in leaf axils on the upper branches. Usually, six flowers bloom in a bell-shaped involucre of five partly fused bracts. Each five-lobed, funnel-shaped flower is 4 to 6 centimeters (1.6 to 2.4 in) wide and magenta in color.

Among the Zuni people, the powdered root mixed with flour made into a bread and used to decrease appetite. An infusion of the root is taken and rubbed on the abdomen of hungry adults and children. An infusion of the powdered root is taken by adults or children after overeating.

M. multiflora's reproduction is dependent on hawkmoths for pollination. Two primary pollinators are the hawkmoths Hyles lineata and Manduca quinquemaculata.

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