Isocoma acradenia is native to the Southwestern United States (California, Nevada, Utah, Arizona) and northwestern Mexico (Sonora, Baja California). It grows in arid, sandy areas, particularly mineral-rich areas such as alkali flats and gypsum soils.
Along the tough, hard-surfaced stems are linear or oval-shaped glandular leaves 1–6 centimetres (0.39–2.36 in) long, sometimes with stumpy teeth along the edges. They are gray-green and age to pale gray or tan.
The inflorescences along the top parts of the stem branches are clusters of four or five flower heads. Each head is a capsule encased in bumpy, glandular greenish phyllaries bearing many golden yellow disc florets at its mouth. Each disc floret is somewhat cylindrical and protruding.
The fruit is an achene a few millimeters long, with a yellowish pappus adding another few millimeters.